Researchers at NTU discover the reason for Malaria’s drug resistance

Can targeting at the liver stage help in this regard

Biotechin.Asia

Pic courtesy: Nanyang technological university Pic courtesy: Nanyang technological university

Researchers at Singapore’s Nanyang Technological University, lead by Dr. Zbynek Bozdech have discovered the mechanism by which the malaria parasite is developing resistance to key front-line drugs used for its treatment, such as artemisinin.

Malaria is caused by a parasite, Plasmodium which is transmitted to humans via the bites of infected mosquitoes. They infect red blood cells causing symptoms such as fever and vomitting and if left untreated, could prove fatal. In 2013, an estimated 198 million cases of malaria were reported worldwide, with an estimated 584,000 deaths. One of the key intervention strategies to control malaria include artemisinin-based combination therapies and indoor residual spraying with insecticide to control the mosquitoes carrying the parasite.However, there is an emerging parasite resistance to artemisinin and if the mechanism by which the parasite is developing drug resistance is not understood, there could be a rise in global malaria…

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