Special Microorganisms produce Anti-Obesity molecule in the gut

Gut mocrobiota is now the new master regulator of the human physiological and immunological functioning.


Gut bacteriaGut bacteria

Bacteria in the gut fulfil a host of useful function for humans. But recent study says that the gut microbiota can be an effective long-term strategy for inhibiting development of obesity. Researchers at Vanderbilt University in Nashville, Tennessee created a method based on probiotic bacteria to produce an anti-obesity molecule capable of suppressing hunger and thus preventing obesity.

Obesity is a worldwide concern and is known to be strongly associated with the risk of developing many diseases like type 2 diabetes, heart diseases, stroke, etc. The researchers have genetically modified bacteria to generate a molecule that, through normal metabolism, becomes a hunger-suppressing lipid. The strain used in this study is E. coli Nissle 1917 (EcN) which is engineered to make NAPEs.

NAPE (N-acyl-phosphatidylethanolamines) are produced in the small intestine after a meal and are quickly converted into NAE (N-acyl-ethanolamines), potent appetite suppressing lipids.

Once the intestinal bacteria were altered, they were…

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