Origin of Macrophages Paves the Way for Better Therapeutic Design against Diseases


Macrophage engulfing bacteria http://bit.ly/1HAcwgY Macrophage engulfing bacteria http://bit.ly/1HAcwgY

Macrophages are a type of white blood cells essential for the human immune system to protect the body against foreign substances such as virus and bacteria. They also play a crucial role in tissue homeostasis and can contribute to tumor growth and chronic inflammatory diseases such as diabetes, obesity etc. Macrophages are therefore potential drug targets and there is a growing interest in understanding these white blood cells.

The prevailing dogma states that macrophages are produced from monocytes generated in the bone marrow from adult hematopoietic stem cells. However, scientists from the Singapore Immunology Network (SIgN), a research institute under the Agency for Science, Technology and Research (A*STAR), Singapore have shed some light on the origin of adult tissue macrophages. The work was published in the prestigious scientific journal Immunity.

A team of scientists led by Dr. Florent Ginhoux, Principal Investigator of SIgN, A*STAR…

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