2 in 1– Myxoma virus prevents GVHD and kills cancer cells

Biotechin.Asia

Shown here amid red blood cells, hematopoietic stem cells (center) give rise to the cells of the bloodstream http://bit.ly/1HF8OSN Shown here amid red blood cells, hematopoietic stem cells (center) give rise to the cells of the bloodstream http://bit.ly/1HF8OSN

Hematologic malignancies are conditions where the bone marrow is damaged and the body stops to produce normal blood cells, and this calls for a need for allogenic hematopoetic cell transplant (allo-HCT). It is a curative used wherein stem cells from a donor, whose immune system is closely matched to the recipient are transplanted so that body starts producing blood normally. Graft-versus-host disease (GVHD) still remains a main challenge to allo-HCT, reasons being an increased amount of CD3⁺ T lymphocytes in the donor allograft, which causes a delay in the engraftment time, making way for increased risk for disease relapse and opportunistic infections.

A team of health researchers from the University of Florida by teams led by Grant McFadden and Christopher R. Cogle have discovered an ex vivo virtherapy with the oncolytic…

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