Drug interactions catalysed with light

An important breakthrough for the drug interaction studies.


http://bit.ly/1eQjL8v http://bit.ly/1eQjL8v

The liver enzyme cytochrome P450 is responsible for almost all of the drugs and hormone metabolism in all organisms. The enzyme is usually activated by receiving an electron from a co-factor, usually NADPH. The oxidative response of cytochrome P450 has been considered a fundamental factor in new drug development. The cost was so prohibitively expensive that for many decades, cytochrome P450 enzyme was not commercialised and only used for laboratory purposes.

Recently, a team of researchers from the Korea Advanced Institute of Science and Technology (KAIST) have made it possible to use light to produce this expensive metabolic material. In what is called “Whole Cell Photo-Biocatalysis”, Prof Park Chan Beum and Jeong Ki Jun used a photosensitizer eosin Y, which was exposed to light in E.coli bacteria.

Eosin Y can easily enter into the cytoplasm of E.coli and bind specifically to the iron domain of P450. The catalysis…

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