Gut microbiota help limit Type 1 Diabetes by regulating Cathelicidin levels

Biotechin.Asia

A pancreatic islet of Langerhans is expressing the immunoregulator antimicrobial peptide CRAM (in red). The insulin-producting beta-cells are in green and the glucagon-producting alpha-cells are in blue. Credit: Julien Diana A pancreatic islet of Langerhans is expressing the immunoregulator antimicrobial peptide CRAM (in red). The insulin-producting beta-cells are in green and the glucagon-producting alpha-cells are in blue. Credit: Julien Diana

Our body is home to over a trillion microbes called microbiota and houses 10 times more bacteria than cells! While many among these are beneficial to our health, some bacteria known as pathogens can cause infectious diseases, especially when the body’s immune system is compromised.

Researchers from Inserm, Paris Descartes University and the CNRS (French National Centre for Scientific Research), through collaboration with teams from China and Sweden, have recently shown how microbiota protects against the development of type 1 diabetes. The research findings were published in the journal Immunity

Immune system has a range of defense mechanisms including antimicrobial peptides and natural proteins that destroy pathogenic bacteria by disrupting their cell membrane, to defend the body against harmful microbes. Not…

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