Extending lifespan based on insulin sensitivity: Role of Syntaxin 4


Screen Shot 2016-01-24 at 12.08.47 am

Extending lifespan by slowing the process of aging has always been a penchant desire of humanity. Slow aging and long life has been previously associated with higher insulin sensitivity, however, there has not been any established molecular event linking the two.

Recently, researchers at Indiana University School of Medicine (IU) reported a relationship between insulin sensitivity and aging. The group demonstrated a previously unrecognized role of Syntaxin 4 (Syn4) protein in promoting lifespan extension, which is a novel finding.

The process of glucose uptake

Let us try to understand the process of insulin-mediated glucose uptake in cells and the role of Syn4 in the same.

To clear the circulating glucose from blood, hormone ‘insulin’ from β cells of islets of Langerhans in our pancreas stimulates ‘Glucose transporter type 4 (GLUT4)’, stored in the intracellular vesicles in muscle and fat cells, to get fused with the plasma membrane of cells, which…

View original post 357 more words


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s