Extending lifespan based on insulin sensitivity: Role of Syntaxin 4

Biotechin.Asia

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Extending lifespan by slowing the process of aging has always been a penchant desire of humanity. Slow aging and long life has been previously associated with higher insulin sensitivity, however, there has not been any established molecular event linking the two.

Recently, researchers at Indiana University School of Medicine (IU) reported a relationship between insulin sensitivity and aging. The group demonstrated a previously unrecognized role of Syntaxin 4 (Syn4) protein in promoting lifespan extension, which is a novel finding.

The process of glucose uptake

Let us try to understand the process of insulin-mediated glucose uptake in cells and the role of Syn4 in the same.

To clear the circulating glucose from blood, hormone ‘insulin’ from β cells of islets of Langerhans in our pancreas stimulates ‘Glucose transporter type 4 (GLUT4)’, stored in the intracellular vesicles in muscle and fat cells, to get fused with the plasma membrane of cells, which…

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