New Drug Causes Colorectal Cancer Cells to ‘Self-Implode’


“In a way, the cancer cells self-implode because the exposure to the drug activates the mechanism in the cancer cell that actually kill the cells on its own,” said Professor Chng Wee Joo, a senior principal investigator at the Cancer Science Institute of Singapore.

As much as, 900 patients die from colorectal cancer annually in Singapore. Contributing up to 14 % of all cancers in Singapore, the colorectal cancer (also called as colon cancer, rectal cancer or bowel cancer), primarily affects parts of the large intestine (colon and rectum).

However, a recent study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has demonstrated the potential of a small molecule drug, which when combined with chemotherapy is likely to benefit colorectal cancer patients in a synergistic manner. Supported by grants from the National Research Foundation Singapore, Ministry of Education and the…

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