Study links gut neurons & immune system and their role in controlling inflammation


The immune system exercises consistent commitment to strengthen a physique from utmost threats—including what we eat and drink. As the digested food travels through the intestinal system a balancing act is played out. As a contingency measure, the immune cells must remain alert to act against damaging pathogens like Salmonella. However, their activity needs to be gradual else an overreaction can lead to equally harmful consequences like inflammation and tissue damage.

macrophage 1 A schematic representation of intra-tissue macrophage specialization and neuro-immune communication between neurons and macrophages that induces tissue-protective responses to distal perturbations (

A group led by Daniel Mucida, head of the Laboratory of Mucosal Immunology at Rockefeller University found that neurons possibly protect intestinal tissue from over-inflammation. Their new findings were published in Cell on January 14. The group’s commentary on their research could have diagnostic implications for gastrointestinal diseases such as irritable bowel syndrome.

“Resistance to…

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