New Molecule that mimics Exercise could help treat Diabetes and Obesity


Have you ever dreamt of being able to lose weight without doing exercise? Maybe this may come true in near future!

Researchers from the University of Southampton in Britain have created a new molecule that acts as an “exercise mimic” which tricks cells to think that they have run out of energy and thereby alters cellular metabolism. The molecule, which activates AMPK therefore holds much promise as a potential therapeutic agent. This study published in the journal Chemistry & Biology, demonstrates the compound’s potential in treating obesity and type 2 diabetes.

The molecule, labeled “compound 14,” works by inhibiting the enzyme ATIC, which plays a key role in regulating metabolism and insulin signals in the body. As a result, another molecule called ZMP starts accumulating within the cells. The buildup of ZMP tricks the cell into acting as if they are running out of energy. AMPK, the cell’s central energy sensor is activated, causing the…

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